Welcome to the Center for Computer Integrated Systems for Microscopy and Manipulation (CISMM) at UNC Chapel Hill, funded by the National Institutes of Health and National Institute of Biomedical Imaging and Bioengineering through award number 5-P41-EB002025. CISMM develops force technologies applicable over a wide range of biological settings, from the single molecule to the tissue, with integrated systems that orchestrate facile instrument control, multimodal imaging, and analysis through visualization and modeling. Complementing this tool set is the development of a wide range of analysis and visualization tools, in the desktop and in virtual environments, that are being applied to domains from the three dimensional mesh of blood clots, to 3D segmentation in neuroscience up to the clinic in enabling exciting technologies for stroke rehabilitation.
Forces in Biology Workshop: register now!
Come learn about forces in biology at our seventh annual Carolina Workshop on Forces in Biology workshop hosted at UNC May 15-18, 2012 . The Keynote Speaker will be Clare Waterman, Director, Cell Biology and Physiology Center at the National Heart, Lung and Blood Institute, National Institutes of Health.
Yeast Mitotic Spindle Model
This image shows a proposed structure for the mitotic spindle of yeast during metaphase that was produced in collaboration between CISMM personnel and Kerry Bloom’s lab.
This image was an honorable mention in the illustration category of the NSF/Science visualization challenge 2010.
A high-resolution poster version of this image is available for download here. Also featured on Wired Science.
Core Projects develop the technology of our resource
Core 1: Force Microscope Technologies
Core 2: Visual Analytics
Core 3: Biomedical Image Analysis
Core 4: BioInstrumatics
Collaborations form the heart of our resource
Their influence has grown to 18 collaboration projects involving over 28 senior investigator collaborators, with fully one half (9) of the projects located outside of UNC. Collaborators are organized as Collaboration Clusters:
Cell Mechanics Cluster
Lung Cluster
NIH Centers
Medical Cluster
Thrombosis Cluster
Service, Training, and Dissemination
This Resource prides itself on building computer-based tools for microscopy and force measurements to serve the needs of scientists working on the frontiers of knowledge. Our goals are to support visiting scientists, to support Resource-developed hardware/software systems delivered outside the Resource, to support and enhance the research of users who come to our laboratories at UNC.
Service: Come use our resources, either by visiting us at UNC, getting our hardware, or through our free software.
Dissemination: download our software, learn about our work through our publications.
Training: Come learn about forces in biology through our annual Carolina Workshop on Forces in Biology hosted at UNC May 11-13.
Come Use Our Facilities
As an NIH National Research Resource we provide access to our unique facilities to researchers doing related work. Click here to learn more about using this facility.